By Drew Provan
Protecting hematological facets of components corresponding to pathology, molecular technological know-how, melanoma, and normal medication, this consultant comes in handy as a reference for basic perform and medical institution employees, hematologists and trainees in hematology. This moment variation displays advances within the realizing of the molecular biology of sickness because the first version was once released in 1998.
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Extra info for ABC of Clinical Haematology
Blood 1998; 92: 2322–33. Lowenberg B, Downing JR, Burnett A. Acute myeloid leukemia. New England Journal of Medicine 1999; 341: 1051–62. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. New England Journal of Medicine 2006; 12: 166–78. Tauro S, Craddock C, Peggs K et al. Allogeneic stem cell transplantation using a reduced intensity conditioning (RIC) regimen has the capacity to produce durable remissions and long term disease free survival in patients with high risk acute myeloid leukemia (AML) and myelodysplasia (MDS).
Even if the neutrophil count appears normal, neutrophil function can often be poor, particularly in patients with a prior history of myelodysplastic syndrome in which neutrophils are usually dysfunctional. Bleeding Bleeding can occur as a consequence of thrombocytopenia or abnormal coagulation. Spontaneous bruising, gingival bleeding, palatal and retinal haemorrhages, epistaxis, menorrhagia and prolonged bleeding after venepuncture are all relatively common. Infiltration Leukaemic blasts can infiltrate any organ.
Congenital abnormalities Congenital abnormalities of platelets can be divided into disorders of platelet production and those of platelet function. All are very rare. In general, they cause moderate to severe bleeding problems. Increasingly, the molecular basis for these disorders has been characterized and therefore can be used as a diagnostic tool, and may facilitate antenatal diagnosis. Fanconi’s anaemia Fanconi’s anaemia is an autosomal recessive preleukaemic condition, which often presents as thrombocytopenia with skeletal or genitourinary abnormalities.
ABC of Clinical Haematology by Drew Provan