P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna,'s Adjuvant Therapies and Markers of Post-Surgical Minimal PDF

By P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)

ISBN-10: 3642813208

ISBN-13: 9783642813207

ISBN-10: 3642813224

ISBN-13: 9783642813221

P. Denoix and G. Mathe nearly 70% of melanoma sufferers relapse after surgical procedure prior to the fifth 12 months and, typically, for instance in breast carcinoma, they relapse nonetheless later as much as the twentieth 12 months. For a few substantial time, the method of melanoma remedy has been restricted to the sophistication of surgery-radiotherapy combos that maximally diminished the occurrence of neighborhood and neighborhood relapses in websites that have been inside of their succeed in. at the present time, the perform of scientific oncology is unthinkable with out the lively participation of the scientific oncologist. he's the "third guy" of the medical oncology workforce, and he has lately concentrated cognizance at the incontrovertible fact that such a lot relapses come up from far-off metastases as a result of the proliferation of cells seeded there after having left the first tumor web site on the time of operation and, accordingly, are inaccessible to any shape oflocal and/or neighborhood therapy. in this facts, scientific oncologists have proposed the applying of clinical remedies for disseminated minimum residual disorder (MRD). they've got to be had potential: chemother­ apy and immunotherapy. clinical oncologists regularly will be divided into 3 teams: chemotherapists, immunotherapists, and chemoimmunotherapists. The natural chemotherapists, who had already cured a few malignant neoplasias reminiscent of Hodgkin's affliction, acute lymphoid leukemia, placental choriocarcinoma, and Wilms' tumor, proposal they could have the technique of attacking the residual disorder of universal cancers.

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Extra info for Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies

Example text

During this period, aFP was increasing and in spite of radioand chemotherapy, the child died with lung and liver metastasis. Case 3. A hepatoma was detected in a young man of26 [5]. This man was admitted to hospital because of illhealth and digestive troubles. Painful hepatomegaly was observed. The aFP concentration was highly abnormal: 1250 f,Lg/ml. The right lobe ofthe liver was resected and a large tumor (weight 2500 g) removed. The aFP was regularly monitored after surgery (Fig. 3) by means of a technique that detects only concentrations above 1 f,Lg/ml.

Myers, D. J. A. Sutherland, J. W. Meakin, D. G. Malkin, J. A. Kellen, and A. Malkin Introduction Carcinoembryonic antigen (CEA) was originally described by GOLD in 1965. Initial studies suggested that this assay might provide a method for identifying patients with colon cancer. However, the early promise of specificity for colon cancer has not been confirmed by the antigen and antibody preparations currently available and, in fact, abnormally elevated levels ofCEA have been found in a wide variety of tumours, other non-malignant diseases, and after blood transfusion.

Burns, J. : Carcinoembryonic antigen (CEA) assay. A laboratory adjunct in the diagnosis and management of cancer. Hum. Pathol. 5, 139-147 (1974) 3. Maugh II, T. : CEA: Puzzling new information about a useful marker. Science 197, 544 (1977) 4. Myers, R. , Sutherland, D. J. , Kellen, J. , Malkin, D. : CEA in breast cancer. Cancer (in press) (1978) 5. Wang, D. , Bulbrook, R. , Hayward, J. , Hendrick, J. : Relationship between plasma carcinoembryonic antigen and prognosis in women with breast cancer.

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Adjuvant Therapies and Markers of Post-Surgical Minimal Residual Disease I: Markers and General Problems of Cancer Adjuvant Therapies by P. Denoix, G. Mathé (auth.), Professor Gianni Bonadonna, Professor Georges Mathé, Professor Sydney E. Salmon (eds.)


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